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Bisacremines E-G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105
Author
Wu Ping, Xue Jinghua, Yao Lei, Xu Liangxiong, Li Hanxiang, Wei Xiaoyi*
Key Words
DIELS-ALDER REACTION; BIOMIMETIC SYNTHESIS; METABOLITE; STRAIN; BIOSYNTHESIS; BYSSOIDES
Publish on  《ORGANIC LETTERS》 17 4922-4925 2015
Abstract

Three dimeric acremines, bisacremines E-G (1-3), with an unusual carbon skeleton were isolated from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and ECD/TDDFT computations. Compound 3 exhibited inhibitory effects on the production of TNF-alpha, IL-6, and NO in LPS-stimulated macrophages. A biogenetic pathway with a [4 + 2] cycloaddition as the key reaction is proposed for 1-3.

原文链接:http://pubs.acs.org/doi/10.1021/acs.orglett.5b02536

版本所有:中国科学院华南植物园